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Measure oxygen consumption, oxygen extraction fraction (OEF)

Prior OEF mapping requires use of various oxygen-related gas manipulation in positron emission tomography (PET, left) or MRI, which are difficult to perform. QSM based OEF (right) enables manipulation-free mapping in routine MRI.

Cerebral oxygen extraction fraction (OEF): Comparison of challenge-free gradient echo QSM+qBOLD (QQ) with 15 O PET in healthy adults. Cho et al. J Cereb Blood Flow Metab. 2021 Jul;41(7):1658-1668. doi: 10.1177/0271678X20973951.